In 153 cases receiving oral administration of this LPS supplement, significant effect was seen in 23 cases and effectiveness in 67 cases. Improvement ef-fect was seen in a total of 90 cases (58.8%). Severe adverse reactions were seen neither in 58 cases (37.9%) with no obvious improvement nor in five cases with deterioration (3.3%).
Effectiveness of LPS was seen statistically significantly more in male dogs (improvement rate: 69.1%) than in female dogs (im-provement rate: 50.6%) (P = 0.002). The im-provement rate was 80% in Chihuahua, while it was 40% or less in Shih Tzu and toy poodles. This result suggests that effectiveness of LPS depends on the type of dog.
From these findings, LPS derived from Pantoea agglomerans is thought to be a potentially effective supplement for atopic dermatitis in the treat-ment of canine allergic disorders.